Cell-Based Glycoengineering

April 8, 2026

On Feb 2, 2026, Lau et al. published a paper in Frontiers in Immunology titled " Glycoengineering CAR-T cells to overcome galectin-3-mediated immunosuppression.' The research team addresses a critical bottleneck in chimeric antigen receptor (CAR) T-cell therapy: the biochemical vulnerability of engineered cells to the tumor microenvironment (TME). While CAR-T therapy has revolutionized the treatment […]

November 12, 2025

On Nov 6, 2024, Harris et al. published a paper in the journal Cells, titled " Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues". This collaborative research effort, involving experts in synthetic chemistry and cell biology, focused on engineering novel N-Acetyl-D-Glucosamine (GlcNAc) Derivatives. The main finding is that these synthetic analogues—specifically […]