Synthetic Biology-based Glycan Separation and Purification Service
These synthetic biology-based glycan separation and purification services provided by CD BioGlyco are characterized by our efficiency, scalability, and versatility based on our Chassis Development platform. We enable the production of purified Glycan Compounds with high yield and quality, facilitating downstream analysis, characterization, and application in various industries, including pharmaceuticals, biotechnology, and food science. After separation and purification, we also provide the Modification service for our clients. Moreover, clients can find our comprehensive and powerful Chassis for sugar-producing cells on our website.
Synthetic Biology-based Glycan Separation and Purification Service at CD BioGlyco
CD BioGlyco offers glycan separation and purification services using advanced methods like crystallization, extraction, membranes, and distillation. We ensure high-purity glycan for diverse applications.
Crystallization Technology-based Separation and Purification Service
CD BioGlyco leverages crystallization technology to separate and purify glycan molecules. Crystallization exploits the differences in solubility and crystallization kinetics of glycan compounds to isolate them from complex mixtures. This service provides high-purity glycan fractions suitable for various downstream applications.
Extractive Separation Technology-based Separation and Purification Service
CD BioGlyco isolates and purifies glycan molecules from complex matrices by extractive separation technology. This approach involves the use of selective solvents or extraction agents to partition glycan compounds from other components based on their chemical properties. The service ensures efficient and selective separation of glycan species, enabling the production of high-quality glycan extracts.
Membrane Separation Technology-based Separation and Purification Service
CD BioGlyco employs membrane separation technology for the isolation and purification of glycan molecules. Membrane processes such as ultrafiltration, nanofiltration, and reverse osmosis are utilized to selectively separate glycan compounds based on molecular size, charge, and hydrophilicity. This service offers scalable and cost-effective solutions for glycan purification with minimal process steps and reduced solvent usage.
Distillation Technology-based Separation and Purification Service
CD BioGlyco separates and purifies glycan compounds from complex mixtures by distillation technology. Distillation exploits differences in boiling points and vapor pressures of glycan components to achieve separation. Through precise control of temperature and pressure conditions, this service enables the isolation of high-purity glycan fractions suitable for various applications.
Publication Data
Technology: Hydrophilic interaction liquid chromatography (HILIC), Graphitized carbon chromatography, Reversed-phase solid-phase extraction, Capillary electrophoresis (CE), Liquid chromatography (LC), Gel electrophoresis, Mass spectrometry (MS), Matrix-assisted laser desorption/ionization MS
Journal: Analytical and Bioanalytical Chemistry
IF: 4.3
Published: 2017
Results: The research results described in the text discuss the various methods and factors involved in the reversed-phase separation of glycans for analysis. The authors mention that different columns and eluent mixtures have been used, leading to variations in separation efficiency. They also highlight the use of labeling reagents to increase hydrophobicity and detectability of the glycans. The hydrophobicity of the tag was found to influence the separation and elution order of the glycans. The presence of ion-pairing agents, the type of column, the gradient, and the composition of the eluent were identified as factors that influence the elution of glycans. The presence of sialic acids or fucoses on the glycan also has a major influence on the retention, which is linkage specific.
Fig.1 Reversed-phase separation methods for glycan analysis. (Vreeker & Manfred, 2017)
Applications
The synthetic biology-based glycan separation and purification service provided by CD BioGlyco serves diverse applications across the pharmaceuticals, biotechnology, food, and cosmetics industries. Leveraging advanced techniques enables the precise isolation and purification of complex glycans essential for research, development, and large-scale production endeavors. Our service ensures the quality and integrity of glycans, catering to the evolving needs of various sectors reliant on glycan-related products.
Advantages of CD BioGlyco
- CD BioGlyco employs efficient purification methods, optimizing processes to achieve high purity levels while maintaining the integrity of the glycan molecules.
- CD BioGlyco offers tailored solutions for diverse glycan structures, addressing specific client needs and requirements with flexibility and precision.
- CD BioGlyco guarantees high purity and yield in its glycan products with a focus on quality, reliability, and innovation.
CD BioGlyco excels in synthetic biology-based glycan separation and purification services through cutting-edge technology and expertise. Its advantages lie in precise isolation techniques, efficient purification methods, and tailored solutions for diverse glycan structures. Please feel free to contact us for more detiles and a custom quotation!
Reference
- Vreeker, G.C.; Manfred W. Reversed-phase separation methods for glycan analysis. Analytical and Bioanalytical Chemistry. 2017, 409: 359-378.
For research use only. Not intended for any clinical use.
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