Synthetic Biology-based Glycan Modification Service
Three Common Glycan Modification Services at CD BioGlyco
CD BioGlyco provides glycan modification services, utilizing advanced synthetic biology techniques for Glycan Production. Our comprehensive range of services includes chemical synthesis-based glycan modification, polymerization-based glycan modification, and glycan-related plastic modification. With our expertise in synthetic biology, we offer customized solutions to meet diverse glycan modification needs across various applications and industries. Our team is dedicated to delivering high-quality, innovative glycan modification services tailored to the specific requirements of our clients. Clients also can find our GlycoChas™ Cells for glycoproduct production based on synthetic biology that includes such as Plant Chassis, Microalgae Chassis, Fungal Chassis, Bacteria Chassis, and special Cell-free Systems.
Chemical Synthesis-based Glycan Modification Service
Our chemical synthesis-based glycan modification service leverages cutting-edge chemical synthesis techniques to modify glycans with precision and efficiency. Through controlled chemical reactions, we can introduce specific functional groups or structural alterations to glycans, enabling tailored modifications for various research and industrial applications. Our expertise in chemical synthesis ensures the synthesis of complex glycan structures with high purity and reproducibility.
Polymerization-based Glycan Modification Service
With our polymerization-based glycan modification service, we employ polymerization techniques to modify glycans, allowing for the creation of glycan polymers with diverse properties and functionalities. By carefully controlling polymerization conditions, such as reaction time and temperature, we can engineer glycan polymers with customizable molecular weights, branching patterns, and architectures. These modified glycan polymers find applications in areas such as drug delivery, biomaterials, and diagnostics.
Glycan-related Plastic Modification Service
Our glycan-related plastic modification service focuses on modifying plastic materials using glycan-based compounds or derivatives. By incorporating glycan molecules into plastic matrices or modifying the surface properties of plastic substrates, we enhance functionalities such as biocompatibility, adhesion, and biodegradability. This service enables the development of glycan-functionalized plastics for applications ranging from medical devices and implants to environmentally friendly packaging materials.
Publication Data
Technology: Glycan release, Chemical modifications, High-performance liquid chromatography (HPLC), Mass spectrometry (MS), Capillary electrophoresis (CE), Glycome databases
Journal: Journal of Pharmaceutical and Biomedical Analysis
IF: 3.4
Published: 2022
Results: The article discusses the importance of analytical methods and technologies in glycan analysis. It highlights the progress made in comprehensive analytical techniques, which have allowed for large-scale analysis of glycans. The article also mentions the construction of glycome databases and their contribution to understanding the biological functions and significance of glycans. However, it emphasizes the need for further advances in analytical methods and instrumentation to investigate the multilateral functions of glycoprotein glycans in biological and biomedical research. The article acknowledges that while LC- or CE-based glycan profiling and MS-based glycan characterization have improved sensitivity and precision, the sample preparation step remains laborious and time-consuming. Therefore, the improvement of sample preparation methods is crucial for expediting glycobiology research. The article concludes by stating that as glycoscience continues to gain attention, the application of glycoanalytical methodologies is likely to increase with the development of novel analytical tools.
Fig.1 Protein glycosylation and analytical approaches used for glycoprotein glycans. (Kinoshita & Yamada, 2022)
Applications
- Modified glycans play crucial roles in biomedical research, such as studying glycan-protein interactions, cell signaling, and immune responses.
- Glycan modifications are essential in drug development processes, especially in glycoprotein therapeutics. Glycan engineering enables the optimization of drug efficacy, stability, and pharmacokinetics, contributing to the development of novel biologics and vaccines.
- Modified glycans find applications in various biotechnological processes, including enzyme immobilization, biocatalysis, and bioproduction of valuable compounds.
- Glycan modifications contribute to the development of advanced materials with tailored properties, including adhesives, coatings, and biomaterials.
- Glycan modifications enable the development of innovative diagnostic technologies, including biosensors, imaging agents, and point-of-care devices.
Advantages of CD BioGlyco
- CD BioGlyco provides customized solutions to address specific client requirements and project objectives.
- CD BioGlyco offers a comprehensive range of glycan-related services, including synthesis, modification, analysis, and purification.
- CD BioGlyco is dedicated to advancing the field of glycobiology through continuous innovation and research.
Through our glycan modification services, CD BioGlyco empowers researchers and industries to explore the vast potential of glycan engineering and customization, driving innovation and advancements in biotechnology, healthcare, and materials science. Please feel free to contact us in any of your free time to get more information bout our glycan modification services based on our Chassis Development Section.
Reference
- Kinoshita, M.; Yamada K. Recent advances and trends in sample preparation and chemical modification for glycan analysis. Journal of Pharmaceutical and Biomedical Analysis. 2022, 207: 114424.
For research use only. Not intended for any clinical use.
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