Oryza sativa Engineering Service at CD BioGlyco

Oryza sativa, also known as rice, is an important plant species for synthetic glycobiology research. The main aim of synthetic glycobiology is to design and construct novel carbohydrate structures, particularly glycosylation patterns, by engineering glycan-processing enzymes and metabolite supply lines. Through manipulation of these pathways, researchers use rice engineering to develop specific plant glycoforms that might have higher therapeutic or industrial value. At CD BioGlyco, the GlycoChas™ Cells platform is a multifunctional engineering system that includes multiple Plant Chassis including rice, providing clients with professional Oryza sativa engineering service. Oryza sativa engineering in synthetic glycobiology covers multiple fields such as gene editing, metabolic engineering, and synthetic biology. Through the comprehensive application of these technologies, a variety of glycans and glycoproteins of important value can be produced.

• Gene editing technology: We use tools such as CRISPR-Cas9 to precisely manipulate plant genomes in rice engineering. Additionally, other gene editing technologies such as transcription activator-like effector nucleases and zinc finger nucleases are also used.
• Metabolic engineering technology: This technology mainly involves the modification and optimization of metabolic pathways to improve the production and quality of carbohydrates and glycoproteins. The metabolic pathways in rice are modified by introducing exogenous genes or modifying endogenous genes to optimize the synthesis of carbohydrates and glycoproteins. For example, the content of sucrose or starch can be increased by enhancing the activity of sucrose synthase or starch synthase.
• Synthetic biology technology: This technology aims to design and construct new metabolic pathways to produce carbohydrates or glycoproteins that do not originally exist in rice.

Additionally, computational predictive modeling techniques help predict and analyze the structure-function relationships of glycans and improve glycan engineering strategies.

In rice, a variety of carbohydrates and glycoproteins can be produced through synthetic glycobiology. The plant naturally produces a variety of glycan polymers, including cellulose, hemicellulose, and pectin. Depending on the specific modification introduced, the plant can be modified to produce new glycans or glycoproteins.

Applications of Oryza sativa Engineering

• Synthetic glycobiology allows us to design and customize glycan chain synthesis pathways. In rice, this can be achieved by introducing or modifying specific glycosyltransferase and glycosidase genes to synthesize glycan chains of specific structures.
• Rice's glycan sensing and signal transduction mechanisms are critical to its growth and metabolism. Through synthetic glycobiology methods, glycan sensing receptors and downstream signal transduction pathways in rice can be studied and regulated to optimize its response to glycan and utilization efficiency.
• Through synthetic glycobiology methods, the glycan metabolism pathways in rice can be optimized to improve the synthesis efficiency and yield of glycans.
• Through synthetic glycobiology methods, the biosynthetic pathway of glycoconjugates in rice can be studied and enhanced to improve the quality and nutritional value of rice. For example, increasing the synthesis of cellulose or pectin in the cell wall can improve the storage stability and taste of rice.

CD BioGlyco provides professional and comprehensive Oryza sativa engineering services. We not only provide clients with high-quality rice chassis but also produce a series of glycan and glycoprotein products with superior performance and application prospects. We look forward to cooperating with you to create a better future. Clients are welcome to contact us to explore more possibilities together.

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