Synthetic Biology-based Fermentation Development Service
CD BioGlyco offers a synthetic biology-based fermentation development service, specializing in enzyme development and fermentation process optimization. This service harnesses synthetic biology techniques to Engineer Microbial Strains for enhanced enzyme production and optimize fermentation processes. By leveraging genetic engineering and metabolic pathway manipulation, CD BioGlyco enables the development of high-yielding and efficient fermentation systems tailored to specific industrial applications. Through comprehensive expertise in molecular biology and fermentation science, they drive innovation in enzyme production and bioprocess optimization to meet the evolving needs of diverse industries.
Fermentation Development Service at CD BioGlyco
After CD BioGlyco's Chassis Strain Development Service and Chassis Strain Screening Service, we offer comprehensive downstream process development services to our clients, particularly focusing on biosynthetic biology-based fermentation development and after Glycan Separation, Purification, and Modification services.
Enzyme Development Service of Fermentation Development
Leveraging synthetic biology, we endeavor to develop and optimize enzyme production processes. This involves the extraction, expression, and purification of enzymes from natural or engineered microorganisms, followed by functional validation and performance tuning. Through customized enzyme and metabolic engineering approaches, we enhance enzyme activity, stability, and substrate specificity to meet our client's specific industrial production needs.
Enzyme Artificial Intelligence Design Service
Structure-Guided Enzyme Development Service
Directed Evolution-based Enzyme Development Service
Fermentation Process Optimization Service
We optimize the fermentation process for our clients to improve product yield, quality, and production efficiency. This includes optimizing fermentation conditions, microbial culture media formulations, operational parameters, and fermentation equipment configurations. We utilize advanced monitoring and control techniques to ensure stable fermentation operations and continually optimize the production process through real-time data analysis and feedback, aiming for optimal economic benefits and product quality.
Optimization Service of Fermentation Media
Optimization Service of Fermentation Condition
Optimization Service of Nutritional Control
Optimization Service of Fermentation Kinetics
Optimization Service of Auxiliary System
Publication Data
Technology: Genetic modification, Traditional gene editing, CRISPR/Cas gene rditing, CRISPR interference
Journal: Fermentation
IF: 3.7
Published: 2023
Results: Corynebacterium glutamicum, a gram-positive microorganism with a 53.8% GC content, is renowned for its tolerance to inhibitors, fast metabolism. Since its glutamic acid production capability in the 1950s, it has become a pivotal amino acid producer in fermentation. Through gene editing techniques, C. glutamicum is now harnessed for various chemical and nutritional productions across industries. Its unique traits include non-toxicity, efficient protein secretion, and resistance to phage infection. Recent advancements in genetic engineering and synthetic biology have propelled its industrial applications, promising sustainable and efficient biosynthesis. This review explores gene editing strategies, transcriptional regulation, and practical applications, envisioning C. glutamicum's role in green biotechnology and industrial production.
Fig.1 Advantages of C. glutamicum chassis cell, gene editing tools, strategies, and applications. (Wang, et al., 2023)
Applications
- Synthetic biology enables the development of microbial strains capable of producing complex glycans with high specificity and yield. This includes the production of glycoproteins, glycolipids, and glycosaminoglycans, which are essential for various biological processes and have numerous applications in therapeutics, diagnostics, and biotechnology.
- Synthetic biology-based fermentation allows for the engineering of glycosylation pathways in microbial hosts to produce glycan structures with tailored properties. This includes the modification of glycan structures to enhance bioactivity, stability, and immunogenicity, as well as the production of glycan libraries for screening and characterization.
- Synthetic biology approaches enable the expression of glycoproteins with defined glycosylation patterns in microbial hosts such as bacteria, yeast, and fungi. This facilitates the production of recombinant glycoproteins for therapeutic use, structural studies, and functional analysis.
- Synthetic biology-based fermentation can be used to enzymatically modify glycan structures through glycosylation, deglycosylation, and glycan remodeling reactions. This allows for the generation of diverse glycan derivatives with altered physicochemical properties and biological functions.
Advantages of CD BioGlyco
- CD BioGlyco possesses expertise in synthetic biology techniques relevant to fermentation development. Our team comprises scientists with deep knowledge of genetic engineering, metabolic pathway engineering, and synthetic biology principles essential for optimizing fermentation processes.
- CD BioGlyco provides tailored fermentation solutions designed to meet the specific needs and objectives of clients. We work closely with clients to understand their requirements and develop customized fermentation strategies optimized for target product synthesis, yield enhancement, and process efficiency.
- CD BioGlyco integrates synthetic biology tools and techniques into fermentation development to enhance productivity, optimize metabolic pathways, and improve product quality. We leverage genetic manipulation, gene editing, pathway engineering, and synthetic biology approaches to engineer microbial hosts for enhanced production of target compounds.
Through our comprehensive biosynthesis platform and GlycoChas™ Cells, CD BioGlyco enables clients to access advanced glycan engineering and Production Solutions, facilitating advancements in glycoscience and biotechnology. Please do not hesitate to contact us for more details and ask for a custom quote!
Reference
- Wang, Y.; et al. Advances in synthetic biology techniques and industrial applications of Corynebacterium glutamicum. Fermentation. 2023, 9(8): 729.
For research use only. Not intended for any clinical use.
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