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On Apr 21, 2022, Kay et al., primarily from the London School of Hygiene & Tropical Medicine (LSHTM), published a paper in the journal Microbial Cell Factories titled "Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines". The paper details the successful refactoring of the Campylobacter jejuni N-linked […]

On Dec 20, 2021, Capraz et al. from spanning institutions such as the University of Natural Resources and Life Sciences (BOKU) in Austria, published a paper in the journal eLife, titled "Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor". The paper details a rational, structure-guided approach to enhance the neutralizing capability […]

On Nov 6, 2024, Harris et al. published a paper in the journal Cells, titled " Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues". This collaborative research effort, involving experts in synthetic chemistry and cell biology, focused on engineering novel N-Acetyl-D-Glucosamine (GlcNAc) Derivatives. The main finding is that these synthetic analogues—specifically […]

On Oct 8, 2021, Hu et al. from State Key Laboratory of Food Science and Technology, Jiangnan University, published a paper in the Biotechnology for Biofuels, titled "Engineering Escherichia coli for highly efficient production of lacto-N-triose II from N-acetylglucosamine, the monomer of chitin". The core of their work is the development of an engineered Escherichia […]

On May 26, 2025, Hao, Liao, and Lyu from the State Key Laboratory of Pathogen and Biosecurity at the Beijing Institute of Biotechnology published a paper titled "Biosynthesis of Two Types of Exogenous Antigenic Polysaccharides in a Single Escherichia coli Chassis Cell" in Life. This work introduces a robust Synthetic Biology Platform that successfully engineers […]

On July 8, 2025, Bidstrup et al., representing institutions such as Cornell University, the University of Maryland, and Stanford University, published a paper entitled "Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments" in ACS Synthetic Biology. The article addresses a fundamental limitation in biomanufacturing: the challenge of predictably attaching N-linked glycans to protein targets […]

On July 18, 2025, Sriram Neelamegham and team at the State University of New York, Buffalo published a paper titled "Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform" in Nature Communications. This paper successfully engineered a mammalian glycosyltransferase (GT) to function as a highly specific glycan-binding protein (GBP). This work demonstrates […]

On March 19, 2024, Bao et al. from Dalian University in China published a paper titled "Construction of an Escherichia coli chassis for efficient biosynthesis of human-like N-linked glycoproteins" in Frontiers in Bioengineering and Biotechnology. This paper details the successful construction of a stable, high-performance Escherichia coli Chassis cell factory designed for the efficient biosynthesis […]