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On Feb 2, 2026, Lau et al. published a paper in Frontiers in Immunology titled " Glycoengineering CAR-T cells to overcome galectin-3-mediated immunosuppression.' The research team addresses a critical bottleneck in chimeric antigen receptor (CAR) T-cell therapy: the biochemical vulnerability of engineered cells to the tumor microenvironment (TME). While CAR-T therapy has revolutionized the treatment […]

On Apr 21, 2022, Kay et al., primarily from the London School of Hygiene & Tropical Medicine (LSHTM), published a paper in the journal Microbial Cell Factories titled "Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines". The paper details the successful refactoring of the Campylobacter jejuni N-linked […]

On Dec 20, 2021, Capraz et al. from spanning institutions such as the University of Natural Resources and Life Sciences (BOKU) in Austria, published a paper in the journal eLife, titled "Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor". The paper details a rational, structure-guided approach to enhance the neutralizing capability […]

On Nov 6, 2024, Harris et al. published a paper in the journal Cells, titled " Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues". This collaborative research effort, involving experts in synthetic chemistry and cell biology, focused on engineering novel N-Acetyl-D-Glucosamine (GlcNAc) Derivatives. The main finding is that these synthetic analogues—specifically […]

On May 26, 2025, Hao, Liao, and Lyu from the State Key Laboratory of Pathogen and Biosecurity at the Beijing Institute of Biotechnology published a paper titled "Biosynthesis of Two Types of Exogenous Antigenic Polysaccharides in a Single Escherichia coli Chassis Cell" in Life. This work introduces a robust Synthetic Biology Platform that successfully engineers […]

On July 8, 2025, Bidstrup et al., representing institutions such as Cornell University, the University of Maryland, and Stanford University, published a paper entitled "Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments" in ACS Synthetic Biology. The article addresses a fundamental limitation in biomanufacturing: the challenge of predictably attaching N-linked glycans to protein targets […]

On July 18, 2025, Sriram Neelamegham and team at the State University of New York, Buffalo published a paper titled "Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform" in Nature Communications. This paper successfully engineered a mammalian glycosyltransferase (GT) to function as a highly specific glycan-binding protein (GBP). This work demonstrates […]

On March 19, 2024, Bao et al. from Dalian University in China published a paper titled "Construction of an Escherichia coli chassis for efficient biosynthesis of human-like N-linked glycoproteins" in Frontiers in Bioengineering and Biotechnology. This paper details the successful construction of a stable, high-performance Escherichia coli Chassis cell factory designed for the efficient biosynthesis […]

On Dec 12, 2025, Yimthin et al. from the University of Bern, Agroscope, and the International Livestock Research Institute (ILRI), published a paper in the PLOS Pathogens, titled "Capsular polysaccharide of Mycoplasma mycoides subsp. capri contributes to phenotypic diversity promoting distinctive immune responses". The article explores how surface glycans dictate the relationship between a devastating […]